Log in
A+ A A-

Οmicron - Mild symptoms in children - What we know

Many parents worry about their children having the Omicron variant, either because they have not been vaccinated because they are young (under 5), or because parents read that even several vaccinated people can get sick if they catch the Omicron.

First of all, let's clarify - says Elias Mosialos, Professor of Health Policy at the London School of Economics (LSE) - that contracting Omicron after vaccination does not necessarily mean that it will develop into a serious illness. This is shown by the epidemiological data from the countries where the Omicron variant was widely observed earlier. The majority of those who will get the disease will have mild symptoms, while a significant percentage (30% based on studies in South Africa) will be asymptomatic.

What happens to children

But let's look at the evidence for Omicron's impact on children. You may have noticed that several countries report higher rates of children being treated as the Omicron spreads, compared to the Delta variant. Evidence suggests that babies may also be admitted to hospital.

However, the analysis of the British data, and compared to previous variants, shows that Omicron causes less serious disease in children who will get sick. This is further supported by a new South African analysis of childcare.

Maybe it's good to explain the difference in the scale of imports. That is, as we have a very high number of infections due to the very high transmissibility of Omicron, it makes sense to have a higher number of imports. In other words, the increase in admissions simply describes the current burden on hospitals and not necessarily the hospitalization of children due to serious symptoms.

Let me also remind you that in both England and South Africa, children under the age of 12 are not vaccinated. At the same time, do not forget that very young children have been exposed to a much smaller number of infections. Thus, they do not even have high rates of cross-immunoprotection having been diagnosed with previous infections with other variants of the coronavirus.

It has also not been confirmed that the Omicron variant can cause more severe symptoms in children, compared to previous variants. But looking at the data from the admissions, most of the children admitted to the hospital are not as seriously ill as those admitted during the previous waves.

But what do we know about the number of admissions, the intensity and the duration of the hospitalization of the children who contracted Omicron?

An analysis of around 140 hospitals across the UK shows that of those who were treated with Omicron and were under 17 years old, about 42% were under one year old, compared with 30% in previous waves (data by Isaric).

42% refers to imported cases from mid-December to mid-January. As in South Africa, the United Kingdom observed that children who were hospitalized needed oxygen less frequently than children who were sick with the Delta variant.

However, from the data from England, we also learn that in the age group 2-17, 20 children were hospitalized in the intensive care unit, all of whom were unvaccinated.

Pediatric admissions in England had a shorter duration of hospitalization (less than two days on average) compared to, for example, the first wave of children being hospitalized for about a week. Also, data from NHS England, which analyzed about 50 cases of infants admitted with coronavirus, show that they rarely needed oxygen. For example, only 11% of children under one year of age needed oxygen, compared with about 20% in previous waves.

In fact, more than half of the babies stayed in the hospital to monitor their progress and needed no treatment at all.

But let me mention here that the instructions for admitting someone to the hospital are different by age and how they differ for babies with fever. So let us not forget that when we talk about increased admissions we must compare both the symptoms and the duration of hospitalization, but also whether they needed treatment. For the time being, data from England for very young children show a mild symptom, possibly with a fever and cough.

For example, let's look at the respiratory syncytial virus (RSV), a very common virus that infects many infants and young children. This virus can cause higher admission rates in children under 5 years of age if we compare them to the incidence rates currently induced by Omicron in England in this age group.

The image we have of mild infections in children are different in New York State. There, a relatively higher number of admissions of children has been recorded, especially in those under 4 years old, compared to the previous waves. The preliminary health report states that "the potentially increased severity of the Omicron variant may also play a role in increasing hospitalization rates in children ≤11 years of age, compared with adults and children 12-17 years of age." However, so far this analysis is based only on total admissions, not on how many children needed treatment, such as respiratory support.

I will close with some data from a recent meta-analysis on the long-term COVID syndrome (doi.org/10.1016/j.bbi.2021.12.020). It seems that children, if they get sick, have fewer long-term effects of fatigue compared to adults. Also, it seems that there was no significant effect of the infection on a cognitive level in children who became ill (while it was present in adults).

Finally, it is important to remember that vaccines are safe for pregnant and breastfeeding mothers and that we have evidence that antibodies are passed on to infants and through breastfeeding.

Let us all try to actively protect our own people, of all ages.

How long coronavirus survives in the air according to new research

The coronavirus can lose up to 90% of its infectivity and ability to infect humans within 20 minutes of being in the air and most of this loss has occurred within the first five minutes, according to estimates of British scientists, who have simulated the ability of the virus to survive and infect when exhaled into the air by a carrier, in combination with environmental conditions, in particular humidity.

Omicron variant – The effectiveness of vaccines against the new strain

The appearance of the new omicron strain in South Africa, its high transmissibility, the large number of mutations and its rapid spread around the world have particularly worried scientists globally.

https://www.alteregomedia.org/files/images/vid-ads-close-button.png") center center / cover; z-index: 10001;">

Data on the effectiveness of available vaccines are still early.

The Doctors of the Therapeutic Clinic of the Medical School of the National and Kapodistrian Athens Theodora Psaltopoulou, Panos Malandrakis, Giannis Danasis and Thanos Dimopoulos summarize three recent relevant publications in the prestigious international journal Nature.

Multiple mutations (37 to 15 in the spike region of the virus) of the strain in the spike region of the virus raise concerns about whether existing vaccines provide effective immunity to Omicron.

A study (doi: https://doi.org/10.1038/d41586-021-03826-3) showed that the new strain is resistant to the serum neutralization of people who had been ill, as well as the serum of people who had been vaccinated with one of the approved vaccines.

Even serum from subjects receiving booster doses had reduced neutralizing ability against the Omicron strain.

As for monoclonal antibodies, their effectiveness against the new strain is reduced, even those that have already been approved and administered.

Another study (doi: https://doi.org/10.1038/d41586-021-03824-5) after sequencing of the gene of the Omicron strain showed that it also requires the ACE2 receptor to infect human cells.

In serum samples from persons that were both vaccinated and fallen ill and those vaccinated alone, the neutralization of the Omicron strain provided by the vaccines was 22 times less than that of the original Wuhan strain.

In individuals who had become ill and received two doses of vaccine, the neutralization of the Omicron strain was equivalent to the neutralization provided only by the vaccine without a history of disease compared to the original strain of the virus.

Decreased immunity due to Omicron

In conclusion, this study concludes that although the immunity provided by vaccines is reduced, they certainly provide some protection especially with booster doses.

A third study (doi: https://doi.org/10.1038/d41586-021-03825-4), also published in the journal Nature, confirmed reduced efficacy against the Omicron variant, possibly exceeding the third dose.

Antibodies against the RBM region lost their  in vitro potency for the Omicron strain, with only 3 of 29 retaining their efficacy (including ACE-2 mimetic antibody S2K146). Also other antibodies that do not target RBM were effective against the Omicron such as sotrovimab, SX259 and S2H97.

The escape of the micron strain from antibody protection is a key antigenic change in the evolutionary course of the SARS-CoV-2 virus. Therefore, it is particularly important to administer the third booster dose in conjunction with known protective measures, in order to limit the spread of the Omicront strain and in particular to prevent disease from it.

Subscribe to this RSS feed